Activity Test of Pomegranate (Punica granatum L.) Peel Water Extract on Male Rabbit Hair Growth
DOI:
https://doi.org/10.66340/dhcbvk64Keywords:
Pomegranate peel, Hair growth, Male rabbitAbstract
Pomegranate (Punica granatum L.) has been empirically used to stimulate hair growth. This study aims to evaluate the activity of pomegranate peel water extract in promoting hair growth in local male rabbits. The experiment was conducted on rabbits whose back fur had been shaved, then divided into six treatment groups with a shaved area measuring 2 × 2 cm. Each group consisted of four rabbits. The treatment groups included a positive control (2% minoxidil), a negative control (distilled water), a normal control (no treatment), and groups with extract concentrations of 3%, 5%, and 10%. The test material was applied topically twice daily, in the morning and evening. Hair length measurements were taken on days 9, 12, 15, 18, and 21. Based on the results of the post hoc LSD test, the 5% extract concentration showed the optimal effect on hair growth, with no significant difference compared to the positive control group (p = 0.068). The positive control group showed significant differences (p < 0.05) compared to the 3% and 10% extract groups, the negative control, and the normal control. These findings indicate that a 5% water extract of pomegranate peel (Punica granatum L.) can optimally enhance hair growth.
References
Anisah, S., Prabandari, S., & Ikhsanudin, M. (2017). Pengaruh konsentrasi ekstrak daun teh (Camellia sinensis L.) sebagai pertumbuhan rambut pada kelinci (Lepus spp. ) dengan metode maserasi. Parapemikir : Jurnal Ilmiah Farmasi, 6(2). https://doi.org/10.30591/pjif.v6i2.589
Ateeq Ahmad, S. S. (2015). A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia. Journal of Clinical & Experimental Dermatology Research, 06(01). https://doi.org/10.4172/2155-9554.1000253
Bhinge, S. D., Bhutkar, M. A., Randive, D. S., Wadkar, G. H., Todkar, S. S., Savali, A. S., & Chittapurkar, H. R. (2021). Screening of hair growth promoting activity of Punica granatum L. (pomegranate) leaves extracts and its potential to exhibit antidandruff and anti-lice effect. Heliyon, 7(4), e06903. https://doi.org/10.1016/j.heliyon.2021.e06903
Daud, A., Suriati, S., & Nuzulyanti, N. (2020). Kajian Penerapan Faktor yang Mempengaruhi Akurasi Penentuan Kadar Air Metode Thermogravimetri. Lutjanus, 24(2), 11–16. https://doi.org/10.51978/jlpp.v24i2.79
Departemen Kesehatan RI, RI. (2017). Farmakope Herbal Indonesia Edisi II Tahun 2017 (2 ed.). Kemenkes.
Du, F., Li, J., Zhang, S., Zeng, X., Nie, J., & Li, Z. (2024). Oxidative stress in hair follicle development and hair growth: Signalling pathways, intervening mechanisms and potential of natural antioxidants. Journal of Cellular and Molecular Medicine, 28(12), e18486. https://doi.org/10.1111/jcmm.18486
Harris, B. (2021). Kerontokan dan kebotakan pada rambut. Ibnu Sina, 20(2).
Krisnawati, M. (2020). Uji aktivitas sediaan krim ekstrak etanol daun pare (Momordica charantia L.) Terhadap pertumbuhan rambut kelinci galur lokal. Jurnal Ilmiah Farmacy, 7.
Santika, M., Qonitah, F., & Ariastuti, R. (2024). Evaluasi sifat fisik sediaan. 02(02).
Sari, R. P., & Laoli, M. T. (2019). Karakterisasi simplisia dan skrining fitokimia serta analisis secara klt. JIFI (Jurnal Ilmiah Farmasiimelda), 2(2).
